Abstract #2834
Assessing inter-subject variability of white matter response functions used for constrained spherical deconvolution
Ben Jeurissen 1 , Jan Sijbers 1 , and Jacques-Donald Tournier 2,3
1
iMinds-Vision Lab, Dept. of Physics,
University of Antwerp, Antwerp, Belgium,
2
Centre
for the Developing Brain, King's College London, London,
United Kingdom,
3
Dept.
of Biomedical Engineering, King's College London,
London, United Kingdom
A crucial step in spherical deconvolution of
diffusion-weighted MRI images is the definition of the
single fiber response function. On one hand, advanced
methods have been proposed to estimate per-subject
response functions from the data. On the other hand,
there is anecdotal evidence that these responses are
relatively stable across subjects, advocating the use of
a canonical response. In this study we investigate the
inter-subject variability of the single fiber response
from a large collection of data sets from unrelated
healthy adult volunteers. Our findings suggest that in
healthy volunteers the inter-subject variability is low,
supporting the canonical response hypothesis.
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