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Abstract #2834

Assessing inter-subject variability of white matter response functions used for constrained spherical deconvolution

Ben Jeurissen 1 , Jan Sijbers 1 , and Jacques-Donald Tournier 2,3

1 iMinds-Vision Lab, Dept. of Physics, University of Antwerp, Antwerp, Belgium, 2 Centre for the Developing Brain, King's College London, London, United Kingdom, 3 Dept. of Biomedical Engineering, King's College London, London, United Kingdom

A crucial step in spherical deconvolution of diffusion-weighted MRI images is the definition of the single fiber response function. On one hand, advanced methods have been proposed to estimate per-subject response functions from the data. On the other hand, there is anecdotal evidence that these responses are relatively stable across subjects, advocating the use of a canonical response. In this study we investigate the inter-subject variability of the single fiber response from a large collection of data sets from unrelated healthy adult volunteers. Our findings suggest that in healthy volunteers the inter-subject variability is low, supporting the canonical response hypothesis.

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