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Abstract #2854

Studying white matter tractography reproducibility through connectivity matrices

Gabriel Girard 1,2 , Kevin Whittingstall 3 , Rachid Deriche 2 , and Maxime Descoteaux 1

1 Sherbrooke Connectivity Imaging Lab (SCIL), Universit de Sherbrooke, Sherbrooke, Quebec, Canada, 2 Project Team Athena - INRIA, Sophia Antipolis, France, 3 Department of Diagnostic Radiology, Faculty of Medicine and Health Science, Universit de Sherbrooke, Sherbrooke, Quebec, Canada

In this study, we investigate the reproducibility of the connectivity matrix, resulting from different tractography parameters. We vary the number of streamlines used to construct the matrix in cortical to cortical connectivity and analyze its effects. We show that the reproducibility of the connectivity is surprisingly similar across tractography pipeline. In all cases, connectivity matrices tend to stabilize using more than 100,000 streamlines. We found that the analysis of the reproducibility of tractography is a first step to find which tractography pipeline is more characteristic of the underlying anatomical structure.

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