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Abstract #2867

Comparison of seven compartment models of diffusion in prostate tissue

Sisi Liang 1 , Eleftheria Panagiotaki 2 , Peng Shi 1 , and Roger Bourne 3

1 College of Engineering and Science, Victoria University, Melbourne, Vic, Australia, 2 Centre for Medical Image Computing, University College London, London, England, United Kingdom, 3 Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, NSW, Australia

Structure-based modelling of DWI in tissue is becoming a powerful tool for probing microstructure and pathology. A recent study demonstrated the feasibility of a three-component structure-based model called VERDICT for imaging prostate cancer in vivo with DWI at clinical setting with high sensitivity and specificity. Motivated by this new finding, this work investigated the non-perfusion components of the VERDICT model in prostate tissue ex vivo at 9.4 T. Seven compartment models with up to 3 components were compared using Akaikes information criterion. The best-performed model had two compartments with one anisotropic and one restricted compartment.

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