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Abstract #2866

Double-Pulsed Gradient Spin-Echo from DTI in the Fibromuscular Stroma of the Prostate

Scott A. Willis 1 , Timothy Stait-Gardner 1 , William S. Price 1 , and Roger Bourne 2

1 Nanoscale Organisation and Dynamics Group, School of Science and Health, University of Western Sydney, Sydney, NSW, Australia, 2 Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, NSW, Australia

Self-diffusion reports on binding events, restrictions and anisotropies of the system from porous rock to biological tissue, and can be measured using pulsed gradient spin-echo (PGSE) NMR. Double-pulsed gradient spin-echo (DPGSE) is useful for probing molecular dynamics as well as pore sizes and orientation, giving more information than single PGSE measurements. This work investigates angular DPGSE profiles (i.e., equivalent gradient strengths for each PGSE block of the DPGSE but with varying angular separation) in prostate tissue and the use of DTI results to simulate the DPGSE profile for a one-voxel DPGSE measurement.

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