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Abstract #2865

Intravoxel Incoherent Motion Imaging of Renal Fibrosis: A Murine Model Study of Unilateral Ureteral Obstruction

Tong San Koh 1 , Septian Hartono 1 , Tiffany P. Hennedige 1 , Yet Yen Yan 1 , In Chin Song 2 , Lin Zheng 2 , Wing Sum Lee 2 , Helmut Rumpel 3 , Laurent Martarello 4 , James B.K. Khoo 1 , Dow-Mu Koh 5 , and Choon Hua Thng 1

1 National Cancer Centre Singapore, Singapore, Singapore, 2 SingHealth Experimental Medicine Centre, Singapore, Singapore, 3 Singapore General Hospital, Singapore, Singapore, 4 Roche-Singapore Translational Medicine Hub, Singapore, Singapore, 5 Royal Marsden Hospital, Surrey, United Kingdom

The purpose of this study was to explore possible alterations in intravoxel incoherent motion (IVIM) model diffusion and perfusion parameters with the development of fibrosis in the kidney, using a murine model of unilateral ureteral obstruction (UUO). IVIM analysis revealed a decrease in both D and f in the renal parenchyma with the development of fibrosis, and suggested possible microvascular contribution to the reduction in ADC.

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