Abstract #2865
Intravoxel Incoherent Motion Imaging of Renal Fibrosis: A Murine Model Study of Unilateral Ureteral Obstruction
Tong San Koh 1 , Septian Hartono 1 , Tiffany P. Hennedige 1 , Yet Yen Yan 1 , In Chin Song 2 , Lin Zheng 2 , Wing Sum Lee 2 , Helmut Rumpel 3 , Laurent Martarello 4 , James B.K. Khoo 1 , Dow-Mu Koh 5 , and Choon Hua Thng 1
1
National Cancer Centre Singapore, Singapore,
Singapore,
2
SingHealth
Experimental Medicine Centre, Singapore, Singapore,
3
Singapore
General Hospital, Singapore, Singapore,
4
Roche-Singapore
Translational Medicine Hub, Singapore, Singapore,
5
Royal
Marsden Hospital, Surrey, United Kingdom
The purpose of this study was to explore possible
alterations in intravoxel incoherent motion (IVIM) model
diffusion and perfusion parameters with the development
of fibrosis in the kidney, using a murine model of
unilateral ureteral obstruction (UUO). IVIM analysis
revealed a decrease in both D and f in the renal
parenchyma with the development of fibrosis, and
suggested possible microvascular contribution to the
reduction in ADC.
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