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Abstract #2864

Use of a Multi-Exponential Attenuation Model for Sequential Registration of Diffusion Weighted Imaging in the Abdomen and Pelvis

Matthew R Orton 1 , Neil Peter Jerome 1 , Evangelia Kaza 1 , David J Collins 1 , Dow-Mu Koh 2 , Bernd Kuehn 3 , and Martin O Leach 1

1 Radiotherapy and Imaging Department, Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 Department of Radiology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom, 3 Siemens Medical Solutions, Erlangen, Germany

Imaging in the abdomen and thorax is more challenging than other regions due to various forms of tissue motion. For diffusion weighted imaging, registration techniques need to be robust to the wide range of image brightness and contrast over the b-values typically used. This abstract presents an image registration algorithm for diffusion weighted images that uses a multi-exponential model of signal attenuation to sequentially synthesize target images with matching brightness and contrast on which to register the source images. This technique is highly effective for removing in-plane motion with coronally acquired images.

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