Multi-site Liver Tumour ADC Reproducibility at 1.5 T
Ryan Pathak 1 , Hossein Ragheb 2 , Neil A Thacker 2 , David Morris 2 , and Alan Jackson 1
The Wolfson Molecular Imaging Centre,
University of Manchester, Manchester, United Kingdom,
for Imaging Sciences, University of Manchester,
Manchester, United Kingdom
ADC is a potential biomarker of cell death, and an early
indicator of treatment success or failure in oncology.
Reported ADC reproducibility has been poor. This is a
multi-site and vendor study in liver metastasis from
colorectal tumours. We compute variation of mean ADC
between sites. We developed a statistical model of
expected errors to highlight the relative importance of
factors affecting reproducibility in an individual. We
use this model to effectively demonstrate that
reproducibility of less than 4% is achievable with
optimisation of factors, such as region size, that
influence the variation in ADC for an individual.
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