Meeting Banner
Abstract #2870

Longitudinal Reproducibility of Quantitative Diffusion Weighted MRI Improved by Spatially Constrained Probability Distribution Model of Incoherent Motion (SPIM)

Sila Kurugol 1 , Moti Freiman 1 , Onur Afacan 1 , Sean Clancy 1 , and Simon K Warfield 1

1 Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States

Diffusion-weighted MRI enables characterization of abnormalities including liver fibrosis and tumors through measurement of variations in the mobility of water molecules. The Intra-voxel incoherent motion (IVIM) model represents the diffusion signal decay with a bi-exponential function with one decay rate parameter for slow, and a second decay rate parameter for fast diffusion associated with microcirculation. Recently, a spatially-constrained probability distribution model (SPIM) was introduced to represent the heterogeneity of the diffusion components with a two-component mixture model with a spatial homogeneity prior. Here, we evaluate the longitudinal reproducibility of parameters estimation using SPIM compared to IVIM in 68 abdominal scans.

This abstract and the presentation materials are available to members only; a login is required.

Join Here