Abstract #2870
Longitudinal Reproducibility of Quantitative Diffusion Weighted MRI Improved by Spatially Constrained Probability Distribution Model of Incoherent Motion (SPIM)
Sila Kurugol 1 , Moti Freiman 1 , Onur Afacan 1 , Sean Clancy 1 , and Simon K Warfield 1
1
Radiology, Boston Children's Hospital and
Harvard Medical School, Boston, Massachusetts, United
States
Diffusion-weighted MRI enables characterization of
abnormalities including liver fibrosis and tumors
through measurement of variations in the mobility of
water molecules. The Intra-voxel incoherent motion
(IVIM) model represents the diffusion signal decay with
a bi-exponential function with one decay rate parameter
for slow, and a second decay rate parameter for fast
diffusion associated with microcirculation. Recently, a
spatially-constrained probability distribution model
(SPIM) was introduced to represent the heterogeneity of
the diffusion components with a two-component mixture
model with a spatial homogeneity prior. Here, we
evaluate the longitudinal reproducibility of parameters
estimation using SPIM compared to IVIM in 68 abdominal
scans.
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