Longitudinal Reproducibility of Quantitative Diffusion Weighted MRI Improved by Spatially Constrained Probability Distribution Model of Incoherent Motion (SPIM)

Diffusion-weighted MRI enables characterization of abnormalities including liver fibrosis and tumors through measurement of variations in the mobility of water molecules. The Intra-voxel incoherent motion (IVIM) model represents the diffusion signal decay with a bi-exponential function with one decay rate parameter for slow, and a second decay rate parameter for fast diffusion associated with microcirculation. Recently, a spatially-constrained probability distribution model (SPIM) was introduced to represent the heterogeneity of the diffusion components with a two-component mixture model with a spatial homogeneity prior. Here, we evaluate the longitudinal reproducibility of parameters estimation using SPIM compared to IVIM in 68 abdominal scans.

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