Abstract #2871
Changes in tissue components with distinct diffusivities rather than cellularity is the major contributor to clinically observed variations of ADC in prostate tissue
Aritrick Chatterjee 1 , Geoff Watson 2 , Esther Myint 3 , Paul Sved 2 , Mark McEntee 1 , and Roger Bourne 1
1
Faculty of Health Sciences, University of
Sydney, Sydney, New South Wales, Australia,
2
Royal
Prince Alfred Hospital, Sydney, New South Wales,
Australia,
3
Douglass
Hanly Moir Pathology, Sydney, New South Wales, Australia
This study investigates the biophysical basis of
clinically observed decrease of ADC in prostate cancer.
ADC predicted from gland component partial volumes
correlated strongly with measured ADC in both fresh and
fixed tissue. Epithelium and lumen partial volumes each
correlated more strongly with measured ADC than
cellularity metrics: nuclear count and nuclear area.
Differences in the partial volume of prostate gland
components having distinct diffusivities, rather than
changes in the conventionally cited cellularity
metrics, are likely to be the major contributor to
clinically observed variations of ADC in prostate
tissue.
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