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Abstract #2872

Optimised VERDICT MRI protocol for prostate cancer characterisation

Eleftheria Panagiotaki 1 , Andrada Ianus 1 , Edward Johnston 2 , Rachel W Chan 2 , Nicola Stevens 2 , David Atkinson 2 , Shonit Punwani 2 , David J Hawkes 1 , and Daniel C Alexander 1

1 Centre for Medical Image Computing, University College London, London, London, United Kingdom, 2 Centre for Medical Imaging, University College London, London, United Kingdom

This method provides a clinically feasible imaging protocol of 10 minutes for prostate tissue characterization with VERDICT (Vascular Extracellular and Restricted DIffusion for Cytometry in tumours). Previous work used long diffusion imaging protocols in the border of what some patients are willing to tolerate. This work uses a computational optimization framework with VERDICT to meet the clinical scan duration that will enable larger clinical trials for widespread translation. Initial results on patients using the optimised protocol show promise for cancer delineation via the microstructural VERDICT estimates.

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