Comparison of NOGSE and PGSE sequences for axon diameter estimation

Two diffusion sequences designed to measure axonal restricted compartment were compared: Pulsed Gradient Spin Echo (PGSE) and Non-Uniform Oscillating Gradient Spin Echo (NOGSE). The validity of NOGSE analytical equations was assessed using Camino. A bootstrap procedure tested the robustness and accuracy of both sequences at different gradient strengths: 40, 80 and 300 mT/m. Results suggest that (i) the precision of axon diameter estimation increases with gradient strength for both techniques and that (ii) accuracy was higher for the NOGSE technique. The current trends pushing for stronger gradients on clinical scanners, NOGSE technique seems a good candidate for quantifying axon microstructure.

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