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Abstract #2883

Variable sample density at high b-values for Radial Diffusion Spectrum Imaging improves angular resolution

Steven Baete 1,2 and Fernando Emilio Boada 1,2

1 Center for Advanced Imaging Innovation and Research (CAI2R), NYU School of Medicine, New York, NY, United States, 2 Center for Biomedical Imaging, Dept. of Radiology, NYU School of Medicine, New York, NY, United States

The angular resolution of Diffusion Spectrum Imaging (DSI) is crucial in accurately determining the complex distributions of intravoxel fiber orientations in the human brain. The recently proposed Radial q-space sampling for DSI (RDSI) has been shown to have improved angular resolution over conventional Cartesian sampling. Further improvements in Orientation Distribution Function (ODF) sampling and angular resolution of DSI can be obtained by optimizing q-space sampling density in RDSI. This can be done using variable density in q-space to minimize the ODF variance, which does not require extra time when a RDSI multi-echo stimulated echo sequence is used.

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