Accelerated motion-robust non-Cartesian multi-shot diffusion-weighted imaging with reconstruction in the image space

We propose a novel non-Cartesian multi-shot DWI technique that achieves high resolution dense k-space sampling by acquisition of multiple anisotropically oversampled acquisitions (so-called "shots") and by reconstruction in the image space. Our approach leverages the coupling between DW images by simultaneously performing model-based HR reconstruction and estimation of a diffusion compartment imaging (DCI) tissue model that describes the local tissue microstructure at each voxel. Our combined approach also enables reconstruction from shots with different subsets of gradients, providing robustness to patient motion and potential for acceleration.

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