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Abstract #2912

Discrimination between tumor-infiltration and vasogenic edema using non-Gaussian diffusion MRI technoques: preliminary experience

Kouhei Kamiya 1 , Yuichi Suzuki 2 , Shota Tanaka 3 , Akitake Mukasa 3 , Masaaki Hori 4 , Harushi Mori 1 , Akira Kunimatsu 1 , Nobuhito Saito 3 , Shigeki Aoki 4 , and Kuni Ohtomo 1

1 Department of Radiology, The University of Tokyo, Bunkyo, Tokyo, Japan, 2 Department of Radiological Technology, The University of Tokyo Hospital, Bunkyo, Tokyo, Japan, 3 Department of Neurosurgery, The University of Tokyo, Bunkyo, Tokyo, Japan, 4 Department of Radiology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan

Prior studies have applied DTI to distinguish glioblastoma infiltration from vasogenic edema. This study investigated the utility of neurite orientation dispersion and density imaging (NODDI) within the peritumoral region of glioblastoma, by comparing with vasogenic edema in meningioma and metastasis. Voxel-by-voxel scattered plot demonstrated that peritumoral region of glioblastoma can be discriminated from vasogenic edema by combination of the diffusion metrics. Though ADC and FA were still more important discriminating factors, addition of NODDI parameters seemed to improve the specificity for tumor infiltration. Our results suggest that NODDI parameters can provide additional information to DTI, and may hopefully differentiate the highly-infilatrated area from less- or non-infiltrated area in the future.

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