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Abstract #2913

Diffusion Kurtosis Imaging of Fibrotic Mouse Kidneys

Birgitte Fuglsang Kjlby 1 , Steen Jakobsen 2 , Jonas Brorson Jensen 2 , Lea Hougaard Pedersen 3 , Louise M Rydtoft 1 , Sune N Jespersen 1,4 , and Brian Hansen 1

1 CFIN, Aarhus University Hospital, Aarhus, Denmark, 2 Nuclear Medicine and PET Center, Aarhus University Hospital, Aarhus, Denmark, 3 Research Lab. for Biochemical Patology, Aarhus University Hospital, Aarhus, Denmark, 4 Dept. of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Magnetic Resonance (MR) Diffusion Kurtosis Imaging (DKI) is sensitive to tissue microstructure but routine clinical utilization has been held back by time consuming acquisition and postprocessing. Recently, a method for fast estimation of mean diffusivity, fractional anisotropy, mean kurtosis and fractional kurtosis anisotropy was proposed. Here we investigate the technique's ability to differentiate normal and diseased tissue using fixed kidneys from a GMO model of kidney fibrosis. We conclude that mean kurtosis and fractional kurtosis anisotropy are candidates of detecting fibrotic kidney tissue while mean diffusivity and fractional anisotropy are insensitive to differences between wild type and GMO kidneys.

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