Abstract #2913
Diffusion Kurtosis Imaging of Fibrotic Mouse Kidneys
Birgitte Fuglsang Kjlby 1 , Steen Jakobsen 2 , Jonas Brorson Jensen 2 , Lea Hougaard Pedersen 3 , Louise M Rydtoft 1 , Sune N Jespersen 1,4 , and Brian Hansen 1
1
CFIN, Aarhus University Hospital, Aarhus,
Denmark,
2
Nuclear
Medicine and PET Center, Aarhus University Hospital,
Aarhus, Denmark,
3
Research
Lab. for Biochemical Patology, Aarhus University
Hospital, Aarhus, Denmark,
4
Dept.
of Physics and Astronomy, Aarhus University, Aarhus,
Denmark
Magnetic Resonance (MR) Diffusion Kurtosis Imaging (DKI)
is sensitive to tissue microstructure but routine
clinical utilization has been held back by time
consuming acquisition and postprocessing. Recently, a
method for fast estimation of mean diffusivity,
fractional anisotropy, mean kurtosis and fractional
kurtosis anisotropy was proposed. Here we investigate
the technique's ability to differentiate normal and
diseased tissue using fixed kidneys from a GMO model of
kidney fibrosis. We conclude that mean kurtosis and
fractional kurtosis anisotropy are candidates of
detecting fibrotic kidney tissue while mean diffusivity
and fractional anisotropy are insensitive to differences
between wild type and GMO kidneys.
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