Diffusion complexity of gray nucleus in Alzheimer' s disease: an initial diffusion kurtosis imaging study
Weiwei Wang 1 , Rui Hu 1 , Ziheng Zhang 2 , Qingwei Song 1 , Ailian Liu 1 , and Yanwei Miao 1
Radiology Department, the First Affiliated
Hospital of Dalian Medical University, Dalian, Liaoning,
Healthcare China, Beijing, China
DTI can investigate the WM microstructural abnormalities
in AD, while not for GM due to the microstructural
abnormalities. Diffusional kurtosis imaging (DKI)
enables the precise quantification of the diffusional
kurtosis, a measure of non-Gaussian diffusion, in GM.
From the study, we investigated the diffusion complexity
of gray nucleus in AD using DKI and found that the DKI
parameters between AD and healthy controls showed
significant difference. The changes of DKI parameters
demonstrate this feature and show correlations with the
mental state of AD. It is useful for evaluating the
structure change of gray nucleus in AD patients.
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