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Abstract #2916

Diffusion complexity of gray nucleus in Alzheimer' s disease: an initial diffusion kurtosis imaging study

Weiwei Wang 1 , Rui Hu 1 , Ziheng Zhang 2 , Qingwei Song 1 , Ailian Liu 1 , and Yanwei Miao 1

1 Radiology Department, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China, 2 GE Healthcare China, Beijing, China

DTI can investigate the WM microstructural abnormalities in AD, while not for GM due to the microstructural abnormalities. Diffusional kurtosis imaging (DKI) enables the precise quantification of the diffusional kurtosis, a measure of non-Gaussian diffusion, in GM. From the study, we investigated the diffusion complexity of gray nucleus in AD using DKI and found that the DKI parameters between AD and healthy controls showed significant difference. The changes of DKI parameters demonstrate this feature and show correlations with the mental state of AD. It is useful for evaluating the structure change of gray nucleus in AD patients.

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