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Abstract #2917

Whole Body Diffusion Weighted Imaging in Multiple Myeloma; A Comparison of Gaussian and Non-Gaussian Diffusion Models for Quantitative Derived Parameters

Arash Latifoltojar 1 , Margaret Hall-Craggs 2 , Alan Bainbridge 2 , Stuart Taylor 3 , Nikos Dikaios 3 , Kwee Yong 3 , Neil Rabin 2 , and Shonit Punwani 3

1 University College London, London, London, United Kingdom, 2 University College London Hospital, London, United Kingdom, 3 University College London, London, United Kingdom

Whole body diffusion weighted imaging (WBDWI) has been used for initial assessment and monitoring treatment response of multiple myeloma patients. In the standard diffusion model, the displacement of freely mobile water molecules is considered to have Gaussian distribution. However, water diffusion in tissue is more complex and several diffusion models (non-Gaussian diffusion models) have been proposed to account for this behavior and provide a more comprehensive analysis of DWI quantitative derived parameters. In this study, we investigated the application of different diffusion models for assessment of WBDWI quantitative parameters in patients with multiple myeloma.

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