Whole Body Diffusion Weighted Imaging in Multiple Myeloma; A Comparison of Gaussian and Non-Gaussian Diffusion Models for Quantitative Derived Parameters
Arash Latifoltojar 1 , Margaret Hall-Craggs 2 , Alan Bainbridge 2 , Stuart Taylor 3 , Nikos Dikaios 3 , Kwee Yong 3 , Neil Rabin 2 , and Shonit Punwani 3
University College London, London, London,
College London Hospital, London, United Kingdom,
College London, London, United Kingdom
Whole body diffusion weighted imaging (WBDWI) has been
used for initial assessment and monitoring treatment
response of multiple myeloma patients. In the standard
diffusion model, the displacement of freely mobile water
molecules is considered to have Gaussian distribution.
However, water diffusion in tissue is more complex and
several diffusion models (non-Gaussian diffusion models)
have been proposed to account for this behavior and
provide a more comprehensive analysis of DWI
quantitative derived parameters. In this study, we
investigated the application of different diffusion
models for assessment of WBDWI quantitative parameters
in patients with multiple myeloma.
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