Effect of Axonal Structure to DKI White Matter Parameters - a Monte Carlo Simulation Study
Jordan Kovar 1 , Rao Gullapalli 2 , and Jiachen Zhuo 2
Physics & Mathematical Sciences, Worcester
Polytechnic Institute, Worcester, Massachusetts, United
Radiology and Nuclear Medicine, University of Maryland
School of Medicine, Baltimore, Maryland, United States
Biophysical modeling of Diffusion Kurtosis Imaging (DKI)
data can provide direct white matter characterization
for intra- and extra-axonal water diffusion properties.
Human and animal studies have indicated that these
parameters are sensitive to specific axonal structure
changes, such as demyelination and axonal loss. However
how exactly the underlying tissue property affects these
WM parameters are little known. In this study is we used
Monte Carlo simulation to investigate the effect of a
few biophysical property of the axonal structure (e.g.
axonal packing density, axon radius and axonal
permeability) to the DKI WM parameters.
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