Meeting Banner
Abstract #2918

Effect of Axonal Structure to DKI White Matter Parameters - a Monte Carlo Simulation Study

Jordan Kovar 1 , Rao Gullapalli 2 , and Jiachen Zhuo 2

1 Physics & Mathematical Sciences, Worcester Polytechnic Institute, Worcester, Massachusetts, United States, 2 Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States

Biophysical modeling of Diffusion Kurtosis Imaging (DKI) data can provide direct white matter characterization for intra- and extra-axonal water diffusion properties. Human and animal studies have indicated that these parameters are sensitive to specific axonal structure changes, such as demyelination and axonal loss. However how exactly the underlying tissue property affects these WM parameters are little known. In this study is we used Monte Carlo simulation to investigate the effect of a few biophysical property of the axonal structure (e.g. axonal packing density, axon radius and axonal permeability) to the DKI WM parameters.

This abstract and the presentation materials are available to members only; a login is required.

Join Here