Abstract #2922
Preliminary Evidence of Midazolam Effect in Brain Microstructure using Diffusional Kurtosis Imaging
Xingju Nie 1 , Dorothea Rosenberger 2 , Aurelie Ledreux 3 , Ann-Charlotte Granholm 3 , Heather Boger 3 , and Maria Falangola 1,3
1
Radiology and Center for Biomedical Imaging,
Medical University of South Carolina, Charleston, South
Carolina, United States,
2
Anesthesiology,
University of Utah, Utah, United States,
3
Neuroscience,
Medical University of South Carolina, Charleston, South
Carolina, United States
Benzodiazepines (BZD) are widely prescribed among older
adults, often for anxiety, depression and insomnia.
Midazolam (MDZ) is the most commonly used BZD
premedication for sedation and in the intensive care
unit. However, the mechanisms of a possible MDZ
neuroprotection or neurotoxicity effects on brain
microenvironment are not fully understood. This study
investigates if MDZ administration in rodents causes
changes in the cerebral microenvironment as defined by
diffusional kurtosis imaging (DKI). We detected DK
metrics increase reflecting changes in the cerebral
microenvironment of the cortex, striatum, thalamus and
hippocampus of rats exposed to MDZ, which may be related
to mitochondrial abnormalities.
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