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Abstract #2923

Clinical application of gamma distribution model for spinal lesions: Initial clinical results

Miyuki Takasu 1 , Koichi Oshio 2 , Yuji Akiyama 1 , Ryuji Akita 1 , Kazushi Yokomachi 1 , Yoko Kaichi 1 , Shuji Date 1 , and Kazuo Awai 1

1 Diagnostic Radiology, Hiroshima University Hospital, Hiroshima, Hiroshima, Japan, 2 Department of Diagnostic Radiology, Keio University, Tokyo, Japan

Non-Gaussian diffusion methods permitting the analysis of the diffusion-weighted signal over a larger range of b-values have gained an increasing importance in tissue characterization. Our purpose was to investigate the applicability and the performance of gamma distribution model in differentiating vertebral lesions in human subjects. For each of normal spinal bone marrow and lesions, , , the area fraction of D < 1.0mm2/s (frac<1), the area fraction of D > 3.0 mm2/s (frac>3), PG (D) and K was measured. , frac <1, PG (D), and K proved to be useful for differentiation of malignant lesions from benign lesions.

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