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Abstract #2932

Towards High Spatial Resolution Diffusion-Sensitized MR Imaging of the Eye and Orbit at 3.0 T and 7.0 T: Quantitative Assessment of the Anatomic Fidelity of EPI and RARE Variants

Katharina Paul 1 , Andreas Graessl 1 , Jan Rieger 1,2 , Darius Lysiak 1,2 , Till Huelnhagen 1 , Lukas Winter 1 , Robin Heidemann 3 , Tobias Lindner 4 , Stefan Hadlich 5 , Paul-Christian Krueger 5 , Soenke Langner 5 , Oliver Stachs 4,6 , and Thoralf Niendorf 1,7

1 Max-Delbrueck Centre for Molecular Medicine, Berlin Ultrahigh Field Facility (B.U.F.F.), Berlin, Berlin, Germany, 2 MRI.TOOLS GmbH, Berlin, Germany, 3 Siemens Healthcare Sector, Erlangen, Germany, 4 University Medicine Rostock, Pre-clinical Imaging Research Group, Rostock, Germany, 5 University of Greifswald, Institute for Diagnotic Radiology and Neuroradiology, Greifswald, Germany, 6 University Medicine Rostock, Department of Ophthalmology, Rostock, Germany, 7 Experimental and Clinical Research Center, a joint cooperation between the Charit Medical Faculty and the Max-Delbrueck-Center, Berlin, Germany

Diffusion-weighted imaging (DWI) of the orbit is an emerging MRI application to provide guidance during diagnostic assessment and treatment of ophthalmological diseases. The standard approach for DWI is EPI. However, EPI is prone to severe geometric distortions, especially at high and ultrahigh magnetic fields. Realizing these constraints and the potential of ocular DWI, this work uses diffusion sensitized multi-shot RARE for ophthalmic MRI. A comparison in terms of geometric distortions of ms-RARE with two EPI variants is performed for brain and ocular imaging at 3.0 T and at 7.0 T.

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