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Abstract #2933

Acquisition of Diffusion MRI data with High Spatial and Angular Resolution on Postmortem Monkey Brains Using 3D Segmented EPI

Longchuan Li 1,2 , Jaekeun Park 2 , Yuguang Meng 3 , Todd Preuss 4 , Xiaodong Zhang 3 , and Xiaoping Hu 2

1 Department of Pediatrics, Marcus Autism Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, United States, 2 Biomedical Imaging Technology Center, School of Medicine, Emory University, Atlanta, GA, United States, 3 Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, GA, United States, 4 Division of Neuropharmacology and Neurologic Diseases, Emory University, GA, United States

2D or 3D standard spin-echo diffusion sequences have been commonly used for collecting diffusion MRI data on postmortem monkey brains. Because of its low sampling efficiency, many parameters including diffusion directions, spatial resolution and diffusion weighting need to be compromised, limiting its application in brain connectivity studies. Here, we developed a pipeline that can acquire dMRI data on ex-vivo monkey brains with high angular resolution (N=128), high spatial resolution (0.5mm isotropic), and high diffusion weightings (b=2000-4000) within 40 hours. Such framework may bridge the rich connectivity information in monkey tracer studies and that in humans via diffusion tractography.

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