Abstract #2933
Acquisition of Diffusion MRI data with High Spatial and Angular Resolution on Postmortem Monkey Brains Using 3D Segmented EPI
Longchuan Li 1,2 , Jaekeun Park 2 , Yuguang Meng 3 , Todd Preuss 4 , Xiaodong Zhang 3 , and Xiaoping Hu 2
1
Department of Pediatrics, Marcus Autism
Center, Children's Healthcare of Atlanta, Emory
University, Atlanta, GA, United States,
2
Biomedical
Imaging Technology Center, School of Medicine, Emory
University, Atlanta, GA, United States,
3
Yerkes
Imaging Center, Yerkes National Primate Research Center,
Emory University, GA, United States,
4
Division
of Neuropharmacology and Neurologic Diseases, Emory
University, GA, United States
2D or 3D standard spin-echo diffusion sequences have
been commonly used for collecting diffusion MRI data on
postmortem monkey brains. Because of its low sampling
efficiency, many parameters including diffusion
directions, spatial resolution and diffusion weighting
need to be compromised, limiting its application in
brain connectivity studies. Here, we developed a
pipeline that can acquire dMRI data on ex-vivo monkey
brains with high angular resolution (N=128), high
spatial resolution (0.5mm isotropic), and high diffusion
weightings (b=2000-4000) within 40 hours. Such framework
may bridge the rich connectivity information in monkey
tracer studies and that in humans via diffusion
tractography.
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