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Abstract #2940

High angularly resolved diffusion imaging with short scan time and low distortion

Tzu-Cheng Chao 1,2 , Jr-Yuan George Chiou 3 , Stephan E. Maier 3 , and Bruno Madore 3

1 Department of Computer Science and Information Engineering, National Cheng-Kung University, Tainan, Taiwan, 2 Institute of Medical Informatics, National Cheng-Kung University, Tainan, Taiwan, 3 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, M.A., United States

High angular resolution diffusion imaging is a useful tool in exploring cerebral microstructure, but long scan times and geometric distortions have impeded its translation to clinical practice. In the present work, a strategy integrating advantages from accelerated multishot diffusion imaging, multiplexed sensitivity encoding and compressed sensing is proposed to provide reductions in scan time and in geometric distortions. Four-fold improvements in distortion level and as much as three-fold reductions in scan time were achieved for HARDI acquisitions.

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