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Abstract #2939

Low frequency OGSE improves axon diameter imaging in monkey corpus callosum over simple PGSE method

Ivana Drobnjak 1 , John Lyon 1 , Andrada Ianus 1 , Daniel C Alexander 1 , and Tim B Dyrby 2

1 Centre for Medical Image Computing, Department of Computer Science, University College London, London, London, United Kingdom, 2 Copenhagen University Hospital Hvidovre, Danish Research Centre for Magnetic Resonance, Hvidovre, Denmark

Axon diameter provides information about the performance of white matter pathways, and imaging it could provide an important insight into brain operation. Whilst majority of current diffusion imaging methods use standard PGSE sequence, various authors suggest that OGSE offers benefits over PGSE for imaging small pores. Here we investigate this by comparing PGSE and trapezoidal OGSE on a monkey corpus callosum. We find that optimised OGSE outperforms the optimised PGSE protocol by increasing sensitivity to smaller axon diameter. Optimized OGSE waveforms have low frequency, a novel finding, since traditionally high frequency has been considered to increase sensitivity to small sizes.

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