Effects of slab boundary artifacts on diffusion measures in 3D multi-slab diffusion imaging

3D multi-slab diffusion imaging suffers from slab boundary artifacts. If the effects were purely multiplicative, the calculation of diffusion measures should not be affected after normalization by the b=0 image. However, several studies have shown slab boundary artifacts in diffusion tensor metrics. In this work, we investigated the effects of saturation, partial volume and B0 inhomogeneity on slab boundary artifacts and diffusion tensor measures (ADC and FA). We found that the slab boundary artifacts are modulated by many factors, which may not be effectively normalized by b=0 image and result in errors in diffusion measures.

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