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Abstract #2949

Constrained optimization of gradient waveforms for isotropic diffusion encoding

Jens Sjlund 1,2 , Markus Nilsson 3 , Daniel Topgaard 3 , Carl-Fredrik Westin 1,4 , and Hans Knutsson 1,5

1 Linkping University, Linkping, Sweden, 2 Elekta Instrument AB, Stockholm, Sweden, 3 Lund University, Sweden, 4 Brigham and Womens Hospital and Harvard Medical School, MA, United States, 5 Center for Medical Image Science and Visualization (CMIV), Linkping, Sweden

We propose a new framework for numerical optimization of diffusion encoding gradient waveforms. The formulation allows explicit control of hardware requirements, including maximum gradient amplitude, slew rate, heating and positioning of RF pulses. The power of the approach is demonstrated by a comparison with previous work on optimization of isotropic diffusion sequences, showing possible gains in diffusion weighting or in heat dissipation.

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