Measuring the influence of vessel geometry on pCASL labeling efficiency

Influence of vessel angulation and presence of vessel bends in the labeling plane on the resulting CBF was studied for a pseudo-continuous ASL through numerical simulations. Experimental comparison by repositioning and angulation of the labeling plane was done in five healthy volunteers. CBF change of less than 5% for plane angulations of up to 30 was expected from simulations and confirmed by experiments. Up to 30% difference in labeling efficiency was expected on tortuous vessels and 8.4% and 16.9% decrease in CBF was observed in the posterior cerebral artery and vertebral artery vascular territories.

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