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Abstract #2961

Cardiac-triggered pCASL: A cost-effective scheme to enhance the SNR of ASL

Yang Li 1 , Deng Mao 1 , and Hanzhang Lu 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States

The current recommended protocol for ASL is to use pseudocontinuous labeling with 3D acquisition after background suppression. With the recommended long labeling time (1.8s) and post-labeling delay time (1.8s), it is generally thought that the effect of cardiac pulsation should be minimal. However, we often observe the existence of large fluctuations in the difference image (control-label) intensity from one volume to another. Here, we show that the global signal fluctuations is largely attributed to cardiac phase differences from one volume to another, and that cardiac-gated pCASL can increase the SNR by 79% at a modest cost of scan time.

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