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Abstract #2962

Independent Determinants of Cerebral Blood Flow from Multiple Post Label Delay Arterial Spin-Labeling and Phase Contrast Angiography Help Differentiate the Influence of Small and Large Arteries

Andrew D. Robertson 1 and Bradley J. MacIntosh 1,2

1 Heart & Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada, 2 Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

This project examined how large and small vessel characteristics contribute to cerebral blood flow (CBF) in chronic stroke. Magnetic resonance imaging methods were used to estimate CBF and cerebrovascular arterial transit time (ATT), as well as the area and blood flow velocity of the bilateral carotid and vertebral arteries. Anterior and posterior cerebrovascular beds were analyzed separately. In the anterior circulation, arterial size and ATT independently contributed to the CBF estimate. In the posterior circulation, only ATT contributed to CBF. This approach to characterizing cerebral hemodynamics may help identify mechanisms related to CBF change during prospective monitoring.

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