Abstract #2962
Independent Determinants of Cerebral Blood Flow from Multiple Post Label Delay Arterial Spin-Labeling and Phase Contrast Angiography Help Differentiate the Influence of Small and Large Arteries
Andrew D. Robertson 1 and Bradley J. MacIntosh 1,2
1
Heart & Stroke Foundation Canadian
Partnership for Stroke Recovery, Sunnybrook Research
Institute, University of Toronto, Toronto, ON, Canada,
2
Department
of Medical Biophysics, University of Toronto, Toronto,
ON, Canada
This project examined how large and small vessel
characteristics contribute to cerebral blood flow (CBF)
in chronic stroke. Magnetic resonance imaging methods
were used to estimate CBF and cerebrovascular arterial
transit time (ATT), as well as the area and blood flow
velocity of the bilateral carotid and vertebral
arteries. Anterior and posterior cerebrovascular beds
were analyzed separately. In the anterior circulation,
arterial size and ATT independently contributed to the
CBF estimate. In the posterior circulation, only ATT
contributed to CBF. This approach to characterizing
cerebral hemodynamics may help identify mechanisms
related to CBF change during prospective monitoring.
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