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Abstract #2963

Feasibility of Quantification of Cerebral Blood Perfusion using Multi-phase Inter-slice Perfusion Imaging

Ki Hwan Kim 1 , Seung Hong Choi 2 , and Sung-Hong Park 3

1 Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, 2 Department of Radiology, Seoul National University College of Medicine, Korea, 3 Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Korea

In this study, we performed multiple time-phase multi-slice bSSFP imaging following the recently-proposed inter-slice perfusion technique termed alternate ascending/descending directional navigation (ALADDIN). The signal characteristics of the multi-phase ALADDIN perfusion images were consistent with simulations based on the general kinetic model. Quantitative perfusion values could be derived by fitting the multi-phase data to the general kinetic model, and the measured cerebral blood flow values were close to the known values. Contributions of arterial blood volume to the measured cerebral blood volume may be high, but further studies are necessary to understand the signal sources of the measured perfusion signals.

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