Feasibility of Quantification of Cerebral Blood Perfusion using Multi-phase Inter-slice Perfusion Imaging
Ki Hwan Kim 1 , Seung Hong Choi 2 , and Sung-Hong Park 3
Department of Bio and Brain Engineering,
Korea Advanced Institute of Science and Technology,
of Radiology, Seoul National University College of
of Bio and Brain Engineering, Korea Advanced Institute
of Science and Technology, Korea
In this study, we performed multiple time-phase
multi-slice bSSFP imaging following the
recently-proposed inter-slice perfusion technique termed
alternate ascending/descending directional navigation
(ALADDIN). The signal characteristics of the multi-phase
ALADDIN perfusion images were consistent with
simulations based on the general kinetic model.
Quantitative perfusion values could be derived by
fitting the multi-phase data to the general kinetic
model, and the measured cerebral blood flow values were
close to the known values. Contributions of arterial
blood volume to the measured cerebral blood volume may
be high, but further studies are necessary to understand
the signal sources of the measured perfusion signals.
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