Abstract #2964
Cerebral perfusion measurements at 17.2 T using pCASL: a feasibility study
Luisa Ciobanu 1 , Lydiane Hirschler 2,3 , Tomokazu Tsurugizawa 1 , Denis Le Bihan 1 , Clment Debacker 2,3 , and Emmanuel L. Barbier 3,4
1
Neurospin, CEA, Gif-sur-Yvette, France,
2
Bruker
Biospin, Wissembourg, France,
3
University
Grenoble Alpes, Grenoble, France,
4
U836,
Inserm, Grenoble, France
The availability of ultra-high field (UHF) preclinical
scanners renders the use of pCASL attractive for
cerebral perfusion measurements in small animals,
benefiting from increased signal to noise-ratio and
longer blood longitudinal relaxation times. However, the
stronger magnetic field can result in higher
physiological noise and increased B0 inhomogeneity at
the labeling plane, thereby limiting the inversion
efficiency. The purpose of this work was to implement
pCASL and test its feasibility at 17.2 T. We obtained
inversion efficiencies higher than 70% and cerebral
blood flow values in agreement with previous reports,
demonstrating the potential of the technique for UHF
applications.
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