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Abstract #2964

Cerebral perfusion measurements at 17.2 T using pCASL: a feasibility study

Luisa Ciobanu 1 , Lydiane Hirschler 2,3 , Tomokazu Tsurugizawa 1 , Denis Le Bihan 1 , Clment Debacker 2,3 , and Emmanuel L. Barbier 3,4

1 Neurospin, CEA, Gif-sur-Yvette, France, 2 Bruker Biospin, Wissembourg, France, 3 University Grenoble Alpes, Grenoble, France, 4 U836, Inserm, Grenoble, France

The availability of ultra-high field (UHF) preclinical scanners renders the use of pCASL attractive for cerebral perfusion measurements in small animals, benefiting from increased signal to noise-ratio and longer blood longitudinal relaxation times. However, the stronger magnetic field can result in higher physiological noise and increased B0 inhomogeneity at the labeling plane, thereby limiting the inversion efficiency. The purpose of this work was to implement pCASL and test its feasibility at 17.2 T. We obtained inversion efficiencies higher than 70% and cerebral blood flow values in agreement with previous reports, demonstrating the potential of the technique for UHF applications.

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