The comparison of ASL features between young and elderly population: Clinically feasible parameter setting for long labeled pseudo-continuous ASL to reduce the sensitivity of delayed arterial transit time
Yasuhiro Fujiwara 1 , Hirohiko Kimura 2 , Tsuyoshi Matsuda 3 , Masayuki Kanamoto 4 , Tatsuro Tsuchida 2 , Kazunobu Tsuji 2 , Nobuyuki Kosaka 2 , and Toshiki Adachi 4
Department of Medical Imaging, Faculty of
Life Sciences, Kumamoto University, Kumamoto, Kumamoto,
of Radiology, University of Fukui, Fukui, Japan,
MR Applications and Workflow, GE Healthcare Japan,
Center, University of Fukui Hospital, Fukui, Japan
The purpose of this study was to optimize imaging
parameters for accurate rCBF using long labeling
duration (LD) and long PLD with higher SNR, which may be
acceptable for clinical practice. First, the perfusion
signal was simulated using a single-compartment model in
each LD, and theoretical SNR efficiency was calculated.
Next, in vivo studies were performed on a 3.0T MRI for
fifteen volunteers. Based on our results, optimal
imaging parameters suggested a combination of LD 3.0 s
and PLD 2.0 s to improve rCBF quantification and allow
sufficient SNR in elderly individuals with long ATT.
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