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Abstract #2965

The comparison of ASL features between young and elderly population: Clinically feasible parameter setting for long labeled pseudo-continuous ASL to reduce the sensitivity of delayed arterial transit time

Yasuhiro Fujiwara 1 , Hirohiko Kimura 2 , Tsuyoshi Matsuda 3 , Masayuki Kanamoto 4 , Tatsuro Tsuchida 2 , Kazunobu Tsuji 2 , Nobuyuki Kosaka 2 , and Toshiki Adachi 4

1 Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan, 2 Department of Radiology, University of Fukui, Fukui, Japan, 3 Global MR Applications and Workflow, GE Healthcare Japan, Tokyo, Japan, 4 Radiological Center, University of Fukui Hospital, Fukui, Japan

The purpose of this study was to optimize imaging parameters for accurate rCBF using long labeling duration (LD) and long PLD with higher SNR, which may be acceptable for clinical practice. First, the perfusion signal was simulated using a single-compartment model in each LD, and theoretical SNR efficiency was calculated. Next, in vivo studies were performed on a 3.0T MRI for fifteen volunteers. Based on our results, optimal imaging parameters suggested a combination of LD 3.0 s and PLD 2.0 s to improve rCBF quantification and allow sufficient SNR in elderly individuals with long ATT.

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