Abstract #2966
The importance of partial volume correction in ASL based studies of cerebral perfusion in Mild Cognitive Impairment: a quantitative comparison
Virginia Mato Abad 1 , Pablo Garca-Polo 2,3 , Juan lvarez-Linera 4 , Ana Frank 5 , Fernando Zelaya 6 , and Juan Antonio Hernndez-Tamames 1
1
LAIMBIO, Universidad Rey Juan Carlos,
Mstoles, Madrid, Spain,
2
Martinos
Center, MGH, M+Visin Advanced Fellowship, Charlestown,
Massachusetts, United States,
3
Center
for Biomedical Technology (CTB-UPM), Madrid, Spain,
4
Hospital
Ruber Internacional, Madrid, Spain,
5
Hospital
Universitario La Paz, Madrid, Spain,
6
Centre
for Neuroimaging Sciences, Institute of Psychiatry,
King's College London, London, United Kingdom
Partial volume effects (PVE) are a consequence of
limited spatial resolution in ASL, where the low
signal-to-noise ratio leads to the need to employ large
voxels, being the value in each voxel the sum of the
contributions of grey matter, white matter and CSF
rather than a single tissue. Although the need for PVE
correction for ASL applications in neurodegenerative
diseases has been well-established; in this work, we
quantitatively demonstrate the effect of PVE correction
in a well-characterised MCI cohort. Our results show how
PVE correction is essential to maximise the predictive
value of ASL in this field of research.
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