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Abstract #2966

The importance of partial volume correction in ASL based studies of cerebral perfusion in Mild Cognitive Impairment: a quantitative comparison

Virginia Mato Abad 1 , Pablo Garca-Polo 2,3 , Juan lvarez-Linera 4 , Ana Frank 5 , Fernando Zelaya 6 , and Juan Antonio Hernndez-Tamames 1

1 LAIMBIO, Universidad Rey Juan Carlos, Mstoles, Madrid, Spain, 2 Martinos Center, MGH, M+Visin Advanced Fellowship, Charlestown, Massachusetts, United States, 3 Center for Biomedical Technology (CTB-UPM), Madrid, Spain, 4 Hospital Ruber Internacional, Madrid, Spain, 5 Hospital Universitario La Paz, Madrid, Spain, 6 Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, United Kingdom

Partial volume effects (PVE) are a consequence of limited spatial resolution in ASL, where the low signal-to-noise ratio leads to the need to employ large voxels, being the value in each voxel the sum of the contributions of grey matter, white matter and CSF rather than a single tissue. Although the need for PVE correction for ASL applications in neurodegenerative diseases has been well-established; in this work, we quantitatively demonstrate the effect of PVE correction in a well-characterised MCI cohort. Our results show how PVE correction is essential to maximise the predictive value of ASL in this field of research.

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