Effects of 24 hour sleep deprivation on cerebral blood flow measured by ASL

The current study investigates the effect of sleep deprivation on cerebral blood flow (CBF) as measured by arterial spin labeling. 39 healthy male volunteers, were scanned on a first morning after sufficient sleep and on a second morning after either normal sleep (n=20, age 22.7 yrs) or 24 hours supervised sleep deprivation (n=19, age 21.8 yrs). Whereas the 24 hour test-retest showed nearly no CBF changes for the normal sleepers, there were wide-spread perfusion changes for the sleep deprived. This is the first study to show significant changes in CBF after sleep deprivation that are not observed after normal sleep.

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