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Abstract #2969

An Exercise-Recovery Protocol Depicts Muscle Perfusion and Capillary Recruitment Heterogeneity in Peripheral Arterial Disease

Jason K Mendes 1 , Christopher J Hanrahan 1 , Jeff L Zhang 1 , Gwenael Layec 2 , Corey Hart 3 , Russell Richardson 3,4 , Sarang Joshi 5 , and Vivian S Lee 4

1 Radiology, University of Utah, Salt Lake City, Utah, United States, 2 Medicine, University of Utah, Salt Lake City, Utah, United States, 3 Exercise and Sports Science, University of Utah, Salt Lake City, Utah, United States, 4 Medicine, University of Utah, Utah, United States, 5 Bioengineering, University of Utah, Salt Lake City, Utah, United States

An exercise-recovery protocol in the MR scanner acts as a stress test to measure muscle ischemic physiology to improve diagnosis and management of peripheral arterial disease (PAD). Evidence suggests changes in the spatial homogeneity of capillary recruitment may be an earlier predictor of PAD progression than measures of vascular reserve. Using an exercise-recovery regimen and arterial spin labeling we demonstrate varying spatial homogeneity of capillary recruitment corresponding to disease progression and exercise induced hyperemia.

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