Abstract #2972
3D GRASE pseudo-continuous arterial spin labeling (pCASL) of preterm human brains
Minhui Ouyang 1 , Peiying Liu 1 , Hanzhang Lu 1 , Tina Jeon 1 , Lina Chalak 2 , Jonathan M Chia 3 , Andrea Wiethoff 1 , Nancy K Rollins 4 , and Hao Huang 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, TX, United
States,
2
Department
of Pediatrics, University of Texas Southwestern Medical
Center, Dallas, TX, United States,
3
Philips
Healthcare, Cleveland, Ohio, United States,
4
Radiology,
Children's Medical Center, Dallas, TX, United States
Arterial spin labeling (ASL) is a noninvasive perfusion
imaging method for quantifying regional CBF using
labeled blood as an endogenous tracer. However, accurate
measurement of regional CBF for the preterm human brains
remains challenging due to extremely slow blood velocity
and no standardized protocol for ASL of preterm brains.
The purposes of our study are 1) to optimize 3D GRASE
pseudo-continuous ASL (pCASL) protocol for highly
reproducible and well validated ASL in preterm human
brain; and 2) to explore the spatiotemporal CBF
distribution and relationship of regional CBF to
regional microstructural changes during the 3rd
trimester.
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