Abstract #2976
Detection of Longitudinal DTI Changes in Multiple Sclerosis Patients Based on Sensitive WM Fiber Modeling
Claudio Stamile 1 , Gabriel Kocevar 1 , Franois Cotton 1,2 , Franoise Durand-Dubief 1,3 , Salem Hannoun 1 , Carole Frindel 1 , David Rousseau 1 , and Dominique Sappey-Marinier 1,4
1
CREATIS (CNRS UMR5220 & INSERM U1044),
Universit Lyon 1, INSA-Lyon, Villeurbanne, France,
2
Service
de Radiologie, Centre Hospitalier Lyon-Sud, Hospices
Civils de Lyon, Pierre-Benite, France,
3
Service
de Neurologie A, Hpital Neurologique, Hospices Civils
de Lyon, Bron, France,
4
CERMEP
- Imagerie du Vivant, Universit de Lyon, Bron, France
In this work we present a new sensitive automated method
to detect small longitudinal variations in diffusion
parameters along the fiber bundle. We applied this
method on two WM fiber bundles, namely the left and
right Corticospinal Tracts and Inferior Fronto-Occipital
Fasciculi of two MS patients. This method improved the
to detect longitudinal variations. It also allows the
distinction between pathological and normal
appearing fibers, both coexisting in a bundle. This new
approach offered the potential to study the relationship
between lesions and distant regions of white matter that
are connected by a subset of pathological fibers.
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