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Abstract #2976

Detection of Longitudinal DTI Changes in Multiple Sclerosis Patients Based on Sensitive WM Fiber Modeling

Claudio Stamile 1 , Gabriel Kocevar 1 , Franois Cotton 1,2 , Franoise Durand-Dubief 1,3 , Salem Hannoun 1 , Carole Frindel 1 , David Rousseau 1 , and Dominique Sappey-Marinier 1,4

1 CREATIS (CNRS UMR5220 & INSERM U1044), Universit Lyon 1, INSA-Lyon, Villeurbanne, France, 2 Service de Radiologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Benite, France, 3 Service de Neurologie A, Hpital Neurologique, Hospices Civils de Lyon, Bron, France, 4 CERMEP - Imagerie du Vivant, Universit de Lyon, Bron, France

In this work we present a new sensitive automated method to detect small longitudinal variations in diffusion parameters along the fiber bundle. We applied this method on two WM fiber bundles, namely the left and right Corticospinal Tracts and Inferior Fronto-Occipital Fasciculi of two MS patients. This method improved the to detect longitudinal variations. It also allows the distinction between pathological and normal appearing fibers, both coexisting in a bundle. This new approach offered the potential to study the relationship between lesions and distant regions of white matter that are connected by a subset of pathological fibers.

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