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Abstract #2977

Individualized prediction of ADHD based on patterns of altered tract integrity over the whole brain: a performance test on adult females with ADHD using diffusion spectrum imaging

Yu-Jen Chen 1 , Yun-Chin Hsu 1 , Yu-Chun Lo 1 , Shur-Fen Susan Gau 2 , and Wen-Yih Isaac Tseng 1,3

1 Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taipei, Taiwan, 2 Department of Psychiatry, National Taiwan University Hospital, Taipei, Taipei, Taiwan, 3 Molecular Imaging Center, National Taiwan University, Taipei, Taipei, Taiwan

In this study, we examined the performance of predicting adult females with ADHD based on the patterns of altered tract integrity over the whole brain. The whole-brain tract information was compared with predefined differences between ADHD and healthy participants to calculate an index as the similarity with ADHD. Our results showed that the prediction performance was high (AUC > 0.8) when we compared the steps with high ES (ES > 0.65) and more continuous neighbors along tracts (CS > 4). To conclude, the information of the whole-brain tracts estimated by tract-based automatic analysis method is potentially useful for predicting adult female with ADHD.

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