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Abstract #2978

Profilometry: towards a more specific characterization of white matter pathways, with application to Multiple Sclerosis.

Michael Dayan 1 , Elizabeth Monohan 2 , Sneha Pandya 1 , Amy Kuceyeski 1 , Thanh Nguyen 1 , Susan Gauthier 2 , and Ashish Raj 1

1 Radiology, Weill Cornell Medical College, New York, NY, United States, 2 Neurology, Weill Cornell Medical College, New York, NY, United States

Tract profiles offer spatial information lacking in typical analysis averaging diffusion MRI metric over reconstructed tracts. Limited research has been performed to jointly analyze multimetric tract profiles and a novel profilometry framework is proposed to do so. An example of application to 141 multiple sclerosis (MS) patients and 15 healthy controls (HC), with both group and single-case comparison, based on myelin water fraction and radial diffusivity profilometry is presented. Significant differences between MS and HC around the lesion locations were found. Single-case analysis revealed that profilometry visualization could be useful to detect deviation from normative data. Profilometry is suggested to provide a more specific characterization of tract microstructure. An open-source package implementing profilometry will be made available.

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