Quantitative Assessment of Diffusional Kurtosis Anisotropy
G. Russell Glenn 1 , Joseph A. Helpern 2 , Ali Tabesh 3 , and Jens H. Jensen 3
Neurosciences & Center for Biomedical
Imaging, Medical University of South Carolina,
Charleston, SC, United States,
Neurosciences, & Center for Biomedical Imaging, Medical
Univesity of South Carolina, Charleston, SC, United
& Center for Biomedical Imaging, Medical Univesity of
South Carolina, Charleston, SC, United States
Fractional anisotropy (FA) is a commonly used parameter
from diffusion MRI data to quantify features of tissue
microstructure. However, FA may take on small values
despite significant diffusional anisotropy in regions
with multiple, non-uniform fiber bundle orientations.
This study will compare FA to measures of anisotropy
that utilize higher order diffusion information from the
kurtosis tensor calculated from diffusional kurtosis
imaging (DKI), including kurtosis fractional anisotropy
(KFA) and generalized fractional anisotropy (GFA). Both
KFA and GFA are shown provide distinct and complementary
information when compared to FA and may be particularly
useful in regions where WM fiber bundles intersect.
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