Meeting Banner
Abstract #2987

Are SHORE-based biomarkers suitable descriptors for microstructure in DSI?

Lorenza Brusini 1 , Mauro Zucchelli 1 , Alessandro Daducci 2 , Cristina Granziera 3,4 , and Gloria Menegaz 1

1 Computer Science, University of Verona, Verona, Verona, Italy, 2 EPFL, Lausanne, Switzerland, 3 Siemens Healthcare IM BM PI & Department of Radiology, CHUV, Lausanne, Switzerland, 4 Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland

Micro-structural indexes based on a novel reconstruction method for diffusion MRI data (SHORE) have recently been proposed and require proper validation. In this work, we derive and analyze SHORE descriptors on a group of human Diffusion Spectrum Imaging (DSI) data. The study aimed at determining their descriptive power, reliability and relations with established indexes of connectivity microstructure. Results suggest that such new biomarkers are sensitive to tissue microstructure properties and allow discriminating not only between white (WM) and gray (GM) matter but also regions with different WM topologies, besides providing an estimate of the ensemble average axons diameter.

This abstract and the presentation materials are available to members only; a login is required.

Join Here