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Abstract #2988

Correcting for perfusion and isotropic free diffusion in diffusion weighted imaging and DTI and CSD analysis

Martijn Froeling 1 , Peter R Luijten 1 , and Alexander Leemans 2

1 Radiology, UMC Utrecht, Utrecht, Netherlands, 2 Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands

In this study, we have investigated the use of Intra voxel incoherent motion (IVIM) modeling in combination with moment nulled diffusion gradients to correct DW imaging data for perfusion and partial volume effects and have tested this method using diffusion tensor imaging (DTI) and constrained spherical deconvolution (CSD) analysis. We have shown that using Asymmetric bipolar diffusion gradients in combination with IVIM correction this bias can be minimized. Furthermore, using 2nd order moment nulled DW sequences prevents signal attenuation due to intra voxel de-phasing originating from velocity and acceleration gradients within a voxel resulting in more reliable IVIM fits.

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