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Abstract #2989

Parameters Estimation for White Matter Microstructure Models using Variable Projection Method and Stochastic Global Search Algorithms

Hamza Farooq 1 , Junqian Xu 2 , Essa Yacoub 3 , Tryphon Georgiou 1 , and Christophe Lenglet 3

1 Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota, United States, 2 Department of Radiology, Icahn School of Medicine, The Mount Sinai Hospital, New York, United States, 3 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, United States

We suggest an improved fitting algorithm for Brain white matter microstructure models to extract parameters like axon radius, fiber orientation and volume fractions of different compartments. Suggested is fast and accurate as compared to traditional techniques. Further, it does not simplify or linearize model to extract the information.

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