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Abstract #2992

Altered structural connectivity between patients with schizophrenia and healthy adults measured by combined direct and indirect connection strengths

Sung-Chieh Liu 1 , Yu-Jen Chen 1 , Yun-Chin Hsu 1 , Tzung-Jeng Hwang 2 , Hai-Gwo Hwu 2 , and Wen-Yih Isaac Tseng 1,3

1 Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taipei, Taiwan, 2 Department of Psychiatry, National Taiwan University Hospital, Taipei, Taipei, Taiwan, 3 Molecular Imaging Center, National Taiwan University, Taipei, Taipei, Taiwan

Schizophrenia (SZ) has been widely considered as a disorder of connectivity between components of large-scale brain networks. Diffusion tensor imaging (DTI) studies have revealed altered white matter structural integrity in some brain regions in SZ, such as cingulum bundles (CB), uncinated fasciculus (UF), corpus callosum (CC), fornix, etc. In this study, we used diffusion spectrum imaging (DSI) tractography and anatomy to find physical connections between pairs of brain regions. Our aim was to find significant differences in structural connectivity strengths between pairs of brain regions, including direct and indirect structural connection, between cortical and subcortical regions between SZ and controls.

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