Abstract #2992
Altered structural connectivity between patients with schizophrenia and healthy adults measured by combined direct and indirect connection strengths
Sung-Chieh Liu 1 , Yu-Jen Chen 1 , Yun-Chin Hsu 1 , Tzung-Jeng Hwang 2 , Hai-Gwo Hwu 2 , and Wen-Yih Isaac Tseng 1,3
1
Center for Optoelectronic Medicine, National
Taiwan University College of Medicine, Taipei, Taipei,
Taiwan,
2
Department
of Psychiatry, National Taiwan University Hospital,
Taipei, Taipei, Taiwan,
3
Molecular
Imaging Center, National Taiwan University, Taipei,
Taipei, Taiwan
Schizophrenia (SZ) has been widely considered as a
disorder of connectivity between components of
large-scale brain networks. Diffusion tensor imaging
(DTI) studies have revealed altered white matter
structural integrity in some brain regions in SZ, such
as cingulum bundles (CB), uncinated fasciculus (UF),
corpus callosum (CC), fornix, etc. In this study, we
used diffusion spectrum imaging (DSI) tractography and
anatomy to find physical connections between pairs of
brain regions. Our aim was to find significant
differences in structural connectivity strengths between
pairs of brain regions, including direct and indirect
structural connection, between cortical and subcortical
regions between SZ and controls.
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