Abstract #3002
Neuroimaging Bridge to CLARITY
Kristi Clark 1 , Farshid Sepehrband 2,3 , Alexander Talishinsky 4 , Samuel Barnes 5 , Russell Jacobs 5 , Shagun Mehta 4 , Celia Williams 4 , and Carol Miller 4
1
Institute for Neuroimaging and Informatics,
University of Southern California, Los Angeles, CA,
United States,
2
Centre
for Advanced Imaging, The University of Queensland,
Brisbane, Australia,
3
Queensland
Brain Institute, The University of Queensland, Brisbane,
Australia,
4
Department
of Pathology, University of Southern California, Los
Angeles, CA, United States,
5
Beckman
Institute, California Institute of Technology, Pasadena,
CA, United States
Advanced microstructural models of diffusion imaging
(dMRI) have the potential to quantify microstructural
changes and map connections. However, these models have
been difficult to validate against a biological gold
standard due to the limitation of histological
techniques, which require physical cutting of the tissue
to view changes two-dimensionally. An exciting new
technique called CLARITY has shown that by dissolving
the lipids in a volume of brain tissue, it is now
possible to study neuroanatomy, especially connectivity,
in three dimensions. In this project, adult human
hippocampal tissue processed with CLARITY is used to
validate microstructural dMRI models.
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