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Abstract #3003

DTI and Molecular Expression Based Studies Detects Radiation Induced Early Acute Neuroinflammatory Changes in Hippocampus

Poonam Rana 1 , Sushanta Kumar Mishra 1 , Mamta Aryabhushan Gupta 1 , Richa Trivedi 1 , B S Hemanth Kumar 1 , and Subash Khushu 1

1 NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, DRDO, Delhi, Delhi, India

Ionizing radiation exposure induced systemic inflammatory response might play an important role in influencing CNS function. The present study has been carried out to identify the changes occurring in brain with special reference to hippocampus within 24 hours of radiation exposure using MR techniques. The results showed changes in mean diffusivity and radial diffusivity at 3 and 24 hrs post irradiation compared to controls. The restricted diffusion as observed in DTI along with increased pro-inflammatory cytokine gene expression by real time-PCR and GFAP expression by immunohistochemistry are suggestive of systemic inflammatory response induced neuroinflammatory changes in brain.

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