Abstract #3003
DTI and Molecular Expression Based Studies Detects Radiation Induced Early Acute Neuroinflammatory Changes in Hippocampus
Poonam Rana 1 , Sushanta Kumar Mishra 1 , Mamta Aryabhushan Gupta 1 , Richa Trivedi 1 , B S Hemanth Kumar 1 , and Subash Khushu 1
1
NMR Research Centre, Institute of Nuclear
Medicine and Allied Sciences, DRDO, Delhi, Delhi, India
Ionizing radiation exposure induced systemic
inflammatory response might play an important role in
influencing CNS function. The present study has been
carried out to identify the changes occurring in brain
with special reference to hippocampus within 24 hours of
radiation exposure using MR techniques. The results
showed changes in mean diffusivity and radial
diffusivity at 3 and 24 hrs post irradiation compared to
controls. The restricted diffusion as observed in DTI
along with increased pro-inflammatory cytokine gene
expression by real time-PCR and GFAP expression by
immunohistochemistry are suggestive of systemic
inflammatory response induced neuroinflammatory changes
in brain.
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