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Abstract #3006

Alterations in white matter tracts in alcohol dependence: A Tract-Based Spatial Statistics (TBSS) based DTI study

Mukesh Kumar 1 , Shilpi Modi 1 , Pawan Kumar 1 , and Subash Khushu 1

1 NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), New Delhi, Delhi, India

The aim of present study was to investigate micro-structural disruption of white matter tracts in alcohol dependant subjects by using Tract-Based Spatial Statistics (TBSS) of DTI measures. DTI was performed on twenty-nine control subjects and twenty-eight alcoholic patients. Our result showed decreased fractional anisotropy in the anterior thalamic radiation, inferior fronto-occipital fasciculus, superior and inferior longitudinal fasciculus, forceps minor,corticospinal, cingulum, uncinate fasciculus in alcohol dependant subjects as compared to controls. These findings suggest that the microstructural changes in these white matter tracts may contribute to underlying dysfunction in cognitive and behaviour as observed in them.

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