Abstract #3005
A method to improve the quality of diffusion MRI with rapid histological correlation in a murine model
Yu-Chun Lin 1 , Chun-Chieh Wang 2 , Gigin Lin 1 , and Jiun-Jie Wang 3
1
Department of Diagnostic Radiology, Chang
Gung Memorial Hospital, Taoyuan, Taiwan, Taiwan,
2
Department
of Radiation Oncology, Chang Gung Memorial Hospital,
Linkou, Taiwan,
3
Department
of Medical Imaging and Radiological Sciences, Chang Gung
University, Yaoyuan, Taiwan
We propose a method to improve diffusion MRI and
facilitate the matching between MR imaging and tissue. A
cryostat embedding medium was used to cover the examined
target during MRI studies. The examined tissue was
sectioned in parallel with the imaging plane. Phantom
experiments demonstrated that the embedding improved the
magnetic field inhomogeneity. Animal experiments
revealed significantly reduced distortions in
diffusion-weighted images in both the axial and coronal
planes. The in vivo MR images were easily matched with
histological specimens in a slice-to-slice fashion. This
method is easy and straightforward to be used in
preclinical studies.
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