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Abstract #3014

Diffusion Tensor Imaging of the human aortic wall: an ex-vivo study

Nicola Martini 1 , Simona Celi 1,2 , Daniele Della Latta 1 , Daniele De Marchi 1 , Giuseppe Valvano 1,3 , Angelo Monteleone 1 , Vincenzo Positano 4 , Maria Filomena Santarelli 4,5 , Sergio Berti 1 , Marco Solinas 1 , Luigi Landini 1,3 , and Dante Chiappino 1

1 Fondazione G.Monasterio CNR-Regione Toscana, Massa, MS, Italy, 2 Scuola Superiore Sant'Anna, Pisa, PI, Italy, 3 Department of Information Engineering, University of Pisa, Pisa, PI, Italy, 4 Fondazione G.Monasterio CNR-Regione Toscana, Pisa, PI, Italy, 5 Institute of Clinical Physiology, CNR, Pisa, PI, Italy

Diffusion tensor imaging (DTI) provides noninvasive information on tissue microstructure. However, the spatial resolution of DTI scans is typically limited by low signal-to-noise ratio and artifact issues that prevent its potential application to small structures, such as vessel walls. In this study we explore the use of a multi-shot EPI sequence for high resolution DTI scans of ex-vivo samples of the human aorta. Different scan protocols are compared to test the influence of scan parameters (resolution, b-value, number of diffusion gradient directions, number of signal averages) on DTI quantitative parameters.

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