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Abstract #3015

Diffusion tensor imaging of the lumbar and sacral plexus in post mortem subjects

Wieke Haakma 1,2 , Michael Pedersen 3 , Martijn Froeling 2 , Lars Uhrenholt 4 , Jeroen Hendrikse 2 , Alexander Leemans 5 , and Lene Warner Thorup Boel 4

1 Department of Forensic Medicine & Comparative Medicine Lab, Aarhus University, Aarhus, Central Denmark, Denmark, 2 Department of Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 3 Department of Comparative Medicine Lab - Clinical Institute, Aarhus University, Central Denmark, Denmark, 4 Department of Forensic Medicine, Aarhus University, Aarhus, Central Denmark, Denmark, 5 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

Diffusion tensor imaging (DTI) allows evaluation of microstructural properties of tissue and is therefore an emerging imaging technique to investigate post-mortem tissue. In this work we examine the architecture and the difference in diffusion values of the lumbosacral plexus in post-mortem subjects using DTI. Reconstructions of the lumbosacral plexus show the architecture of the spine and plexus, lower mean diffusion values compared to in vivo results and nerve injuries in one trauma case. We expect that this technique can provide a valuable contribution to the understanding of pathogenesis and disease progression in peripheral neurological disorders in the future.

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